Dnp is used in developing photography, killing fungi, and as an industrial pesticide. The lowest published lethal human oral dose of dnp is 4. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. There is no compound on earth that can burn fat at the rate of dnp. Full text full text is available as a scanned copy of the original print version. Im including everything i have whether i agree with it or not, because there is no one right way to run dnp. For the sake of clarity, ill use 2,4dnph throughout here. Chemical structure of 2,4 dinitrophenol and sodium dinitrophenolate.
Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. Dinitrophenol for weight loss has been used for almost a hundred years, but was officially deprived of medical drug status in 1938 due to the high. This is a chemical that was once used in the early 20th century to ignite dynamite and cast a yellow dye on wood and other handcrafts. First aid measures general advice consult a physician.
Using 2, 4 dnp as a shell filling was less sensitive than picric acid on its own. This is most of the info i used when i was researching dnp and some new stuff. A few years later demographical statistics showed that employees who worked with dnp everyday tended to lose weight, often rapidly. Safety data sheet northwest missouri state university. It is used in dyes, photo developers, explosives, and as a preservative of lumber. Identification 2,4dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. This page was last edited on 12 february 2016, at 20. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. A few years later demographical statistics showed that employees who worked with.
Everything about dnp 2,4dinitrophenol pharma forums. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. Reason for citation 2,4dinitrophenol is on the hazardous substance list because it is cited by epa. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Associations of 2,4dinitrophenol with other chemical compounds. Sep 01, 2017 the supplement dnp 2 4 dinitrophenol is known for its high toxic but highly effective solution for person who wants to achieve a lot of weight loss. Later on in the 19 th century chemists invented tnt 2,4,6trinitrotoluene and 2,4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings. Also incompatible with strong oxidizing agents, strong bases and reducing agents. Chemical compound and disease context of 2,4dinitrophenol.
Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. The chemical structure of 2,4dinitrophenol is shown in figure 1. Sep 17, 2015 buy dnp 2, 4 dinitrophenol not for human consumption. Reason for citation 2, 4 dinitrophenol is on the hazardous substance list because it is cited by epa. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point. Later on in the 19 th century chemists invented tnt 2, 4,6trinitrotoluene and 2, 4,6trinitrophenol, picric acid, both of which were widely used as explosives in first world war shell fillings.
Buy dnp 2,4dinitrophenol not for human consumption. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Dutch customs has intercepted six different parcel post shipments containing 2,4 dinitrophenol dnp in capsules. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. When in a dry form, it is a high explosive and has an instantaneous explosion hazard. Incompatible with heavy metals and their compounds. Parchem is open and ready to supply materials 18002823982 read more. Analytical, diagnostic and therapeutic context of 2,4. Dnp 2,4 dinitrophenol info with all the dnp threads ive seen lately i thought it would be a good idea to post my compilation of dnp info.
Sep 26, 2019 the atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Merck, darmstadt germany and phenazine methosulfate from calbiochem, inc. Files are available under licenses specified on their description page. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. Get a printable copy pdf file of the complete article 2.
Uses the predominant use of 2, 4 dinitrotoluene is as an intermediate in the manufacture of polyurethanes. Links to pubmed are also available for selected references. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. The supplement dnp 2 4dinitrophenol is known for its high toxic but highly effective solution for person who wants to achieve a lot of weight loss. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. Other pertinent literature is also presented, but is described in less detail than the key studies. Newbies guide to using dnp 2,4dinitrophenol if youve never used dnp before, only take 200mg per day for the first few days. Search results for 2,4dinitrophenol at sigmaaldrich. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2,4dinitrophenol.
Structure, properties, spectra, suppliers and links for. Like tnt, it was found to be toxic to the munition workers handling it. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry. Advice of buro on 2,4dinitrophenol dnp pdf document. It has a role as a bacterial xenobiotic metabolite. It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2,4dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. A year or more ago, i was on an antidepressant regimen that made me gain a lot of weight.
All structured data from the file and property namespaces is available under the creative commons cc0 license. Using 2,4dnp as a shell filling was less sensitive than picric acid on its own. A phenolate anion obtained from 2, 4 dinitrophenol. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2, 4 dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. Dnp is used to increase production of atp and enter body cells. Activation of succinate dehydrogenase by 2,4dinitrophenol.
This page is regularly updated, to include the most recently available clinical trial evidence. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and. The more the atp produced, the higher the metabolism which.
Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc. For additional information on the health effects of this chemical, interested parties are referred to the. It is a yellow, crystalline solid that has a sweet, musty odor. Download scientific diagram chemical structure of 2,4 dinitrophenol and sodium dinitrophenolate pubchem open chemistry database from publication. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. Warnings issued over deadly dnp diet drug thursday 19 september 20 tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Dnp by moving protons across the mitochondrial membrane breaks the process of oxidative phosphorylation, whereby there is an active waste of energy, but without the synthesis of adenosine triphosphate molecules. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this story. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. The mechanism of uncoupling of oxidative phosphorylation. This low dose will also give you time to see how your body reacts to dnp. I am not the original author of this webshell this is a backup repo. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes.
Nov 07, 2016 1 comment on what is 2,4dnph and why are schools carrying out controlled explosions. Its primary function is to produce heat and make less efficient of energy. Any one of six isomeric substituent products of benzene having the empirical formula 2c6h3oh explanation of 2,4dinitrophenol. Identification 2, 4 dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. Preparation of rat liver mitochondria male albino rats weighing 15o17o g from the stock colony were used. Show this safety data sheet to the doctor in attendance. How to sew a reusable face mask with filter pocket diy fabric face mask batch sew medical mask duration. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b.